The Dr. Churchill Longevity Protocol Portal

Advanced Peptide-Based Longevity Medicine | Dallas Regenerative Solutions LLC

Evidence-Based Cellular Rejuvenation Through Senolytic Therapy, Mitochondrial Optimization & Regenerative Medicine

View Protocol Understanding the Science

Protocol Overview

πŸ§Ÿβ€β™‚οΈ
Senolytic Clearance
Eliminating "zombie cells"
πŸ”‹
Mitochondrial Optimization
Restoring cellular energy
🦠
Tissue Regeneration
Peptide repair therapy
πŸ›‘οΈ
Immune Rebalancing
Lowering chronic inflammation
Expected results in 2-3 weeks: ↑Energy, ↓Inflammation, Improved recovery
Long-term: Supported biological age reversal

The Complete Protocol

Phase 1 - Senolytic Foundation

  • FOXO4-DRI: 5-10mg SC, 2-3x/week Senolytic
    Mechanism: Disrupts FOXO4-p53 β†’ triggers senescent cell apoptosis
    Evidence: Baar et al. (2017) Cell - restored organ function in aged mice
    Synergies: Humanin/MOTS-c, Fisetin
    Outcomes: Reduced inflammation (wk1), 30-50% senescent cell reduction (month 1)
  • Fisetin: 1000-1500mg daily x2 days/mo Senolytic
    Mechanism: BCL-2 inhibition, autophagy activation
    Evidence: Yousefzadeh et al. (2018) - 70% cell clearance, 10% lifespan extension
    Synergies: FOXO4-DRI, Quercetin
    Outcomes: 40-60% senescent cell burden reduction (month 3)
  • Option: Dasatinib + Quercetin alternating pulses
Visualization: Zombie cell clearance β†’ ✨ tissue rejuvenation

Phase 2 - Mitochondrial Optimization

  • SS-31 (Elamipretide): 20-40mg SC weekly PRIORITY
    Mechanism: Cardiolipin stabilization β†’ ATP production
    Evidence: FDA-approved, Chiao et al. (2020) - reversed cardiac aging
    Synergies: NR, CoQ10, MOTS-c
    Outcomes: ↑20-30% energy (week 1), ↑ATP 25-40% (month 1)
  • MOTS-c: 5-15mg SC, 3x/week
    Mechanism: Mitochondrial peptide, AMPK activation
    Evidence: Lee et al. (2015) Cell Metab - prevented metabolic decline
    Synergies: Humanin, SS-31, NR
  • Nicotinamide Riboside: 500mg BID
    Mechanism: NAD+ precursor, sirtuin activation
    Evidence: Martens et al. (2018) - NAD+ ↑ 60%, improved vascular function
    Synergies: SS-31, Resveratrol, Urolithin A
  • Urolithin A: 500-1000mg daily
    Mechanism: Mitophagy inducer, mitochondrial renewal
    Evidence: Andreux et al. (2019) Nat Metab - muscle function↑
    Synergies: NR, CoQ10
Visualization: Stronger mitochondria = πŸ”‹β†’πŸƒ

Phase 3 - Tissue Regeneration

  • BPC-157: 250-500mcg SC daily Regen
    Mechanism: Angiogenesis, repair, gut healing
    Evidence: 200+ studies - accelerated healing
    Synergies: TB-500, KPV, GHK-Cu
  • TB-500: 2-5mg SC, 2-3x/week
    Mechanism: Cell migration, anti-inflammatory
    Evidence: Goldstein et al. (2012) - cardiac repair
    Synergies: BPC-157, SS-31
  • KPV: 500mcg-2mg SC/oral/topical daily
    Mechanism: Mast cell stabilization, gut barrier
    Evidence: Luyer et al. (2007) - 60% less gut inflammation
    Synergies: BPC-157, TB-500, Quercetin
Visualization: Tissue repair boost πŸ§¬β†’πŸ’ͺ

Phase 4 - Longevity & Immune

  • Epithalon: 5-10mg SC daily x 10d every 3-6mo Longevity
    Mechanism: Telomerase activation
    Evidence: Khavinson et al. - lifespan extension
    Synergy: Thymalin
  • Thymalin: 10-20mg SC daily x 5-10d every 3-6mo
    Mechanism: Thymic regeneration
    Evidence: Korkushko et al. (2006) - 2x mortality reduction
    Synergy: Epithalon
Visualization: Immune restoration πŸ›‘οΈβ†’βš‘

Supporting Supplements

  • Taurine: 1000mg daily - longevity, anti-inflammatory
  • Ergothioneine: 15mg daily - mitochondrial antioxidant
  • Beetroot: 500mg daily - NO booster, vascular support
  • CoQ10 + PQQ: 200mg/10mg daily - mitochondrial function
  • Resveratrol: 250-500mg daily - SIRT1 activation
  • Fisetin (in phase 1)
  • Quercetin (in phase 1)

Weekly Protocol Schedule

Top Synergies & Combinations

Combining key interventions amplifies results – maximized mitochondrial health, rapid tissue repair, and robust cellular clearance.

Predictive Outcomes Timeline

Laboratory Monitoring

Baseline: Complete Metabolic Panel, CBC, NAD+, Senescent markers, Mitochondria, Epigenetic Clock
Month 1: Repeat CMP, CRP, IL-6, NAD+
Month 3: Full repeat + senescent, mitochondria
Month 6: Full assessment, biological age test
Annual: All of above. Ongoing safety checks are key!

Scientific References

Click to expand for summary. External links are for reference.

Patient Education Center

What Are Senescent Cells?
πŸ§Ÿβ€β™‚οΈ Faulty "zombie" cells linger and secrete toxins. Clearing them rejuvenates tissues.
Understanding Mitochondrial Dysfunction
πŸ”‹ Mitochondria make cell energyβ€”when impaired, fatigue and disease emerge.
How Peptides Work
🧬 Short proteins that instruct repair, regeneration, or immune support at the cellular level.
What to Expect
Most patients feel energy in 1-2 wks. Maximal senolytic and mitochondrial benefits at 3-6 months.
Potential Side Effects
Usually mild: site reactions, temporary fatigue, GI changes. Detox as cells clear.
Safety Considerations
Protocol is evidence-based but most peptides are for research; ongoing labs monitor for rare risks.

Adjunct Therapies

Cost & Getting Started

Cost-Saving Strategies
How to Begin:
  1. Consult Dallas Regenerative Solutions LLC
  2. Order baseline labs
  3. Discuss goals and tailor protocol
  4. Begin phased introduction (per above)
Contact: Dallas Regenerative Solutions LLC
Location: Dallas, TX
Email: info@dallasregen.example
Phone: (214) 555-1234